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This is the approach David Sinclair is best known for

Start low, monitor response over several days (not hours), and adjust slowlythis mirrors the way dose escalation is approached in Phase 1 trials where uncertainty is high and safety is the priority

Although drug injections have been administered in a similar manner for a long time, the guideline for drug injection has been continuously updated based on clinical trials for better treatment with overcoming technical limitations 1, 2, 6,7,8,9

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The TmGst6 gene was highly upregulated in temperature-induced yeast form 9 (This study)