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NCT02570672 ( Metformin for Preventing Frailty in High-risk Older Adults ) is a Phase 2 study involving 120 subjects aged 65 to 90 years old with pre-diabetes and treated with 1000 mg metformin bid, versus placebo, and due for completion in October 2024

Instead, the drug reprograms the metabolism of cells that synthesize and maintain healthy cartilage, allowing them to generate more energy

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