The fact that the majority of L-cells are located distally in the small intestine has prompted attempts to use -glucosidase inhibitors to prevent rapid digestion of starch and complex carbohydrates, thereby moving intestinal contents downwards and resulting in preferential digestion and absorption in the lower jejunum or ileum, where L-cells are most prevalent
A novel oral formulation of the GLP-1 receptor agonist semaglutide (Rybelsus) was recently approved for the treatment of T2DM
To meet the diagnostic criteria for kEDS, a person must meet: Major criterion 1 AND major criterion 2 AND major criterion 3 OR Major criterion 1 AND major criterion 2 AND three minor criteria (general or gene-specific) Major Criteria Congenital muscle hypotonia Congenital or early onset kyphoscoliosis (progressive or non-progressive) Generalized joint hypermobility with dislocations/subluxations (shoulders, hips, and knees in particular) Minor Criteria Skin hyperextensibility Easily bruisable skin Rupture/aneurysm of a medium-sized artery Osteopenia/osteoporosis Blue sclerae Hernia (umbilical or inguinal) Pectus deformity Marfanoid habitus Talipes equinovarus Refractive errors (myopia, hypermetropia) Gene-Specific Minor Criteria PLOD1 Skin fragility (easy bruising, friable skin, poor wound healing, widened atrophic scarring) Scleral and ocular fragility/rupture Microcornea Facial dysmorphology FKBP14 Congenital hearing impairment (sensorineural, conductive, or mixed) Follicular hyperkeratosis Muscle atrophy Bladder diverticula Musculocontractural EDS (mcEDS) If a person meets the diagnostic criteria for mcEDS, genetic testing should be done to confirm the diagnosis
A dermatologist can perform a full assessment and create a plan that could include minoxidil, she explains
For some the benefits are outweighed by the potential side effects: elevated hematocrit levels, estrogen imbalances, and perhaps most alarmingly, shrinking testicles and decreased fertility markers
Understanding the differences helps you choose the right recipes for your specific protocol
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