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10.3892/ijmm.2025.5497 Int

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The trial randomised 2,339 adults with obesity (or overweight with a weight-related comorbidity) and without type 2 diabetes to retatrutide 4mg, 9mg, or 12mg weekly (titrated upward from 2mg in four-weekly steps) or placebo

This article examines the evidence for Ozempic's effects on insulin resistance, who may benefit from treatment, potential side effects, and alternative management approaches in line with UK clinical guidance

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