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Nature, 496 (7443), 110113
This is a huge topic Causes of oxidative stress that have research directly linking them to increased nitric oxide or decreased BH4 include: BPA (a component of some plastics)[ref] Aluminum (also inhibits DHPR in BH4 recycling)[ref] Perfluorinated substances (PFAS, PFOAs)[ref] Vaccination ( Salmonella typhi vaccine)[ref] Chemotherapy [ref] Interferon-alpha treatment[ref] Arthritis and rheumatic diseases[ref] Persistent viral infection, such as in some long Covid patients, hepatitis C[ref][ref] Smoking[ref] An animal study that used a mouse model with genetically reduced GCH1 enzyme found that low BH4 also decreases Nrf2 activation
pronounced muscle weakness
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doi: 10.1038/s41401-020-0380-z 101
Cigna is my employer and I am so grateful they cover these medications and the EncircleRx program has been so helpful too
