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Table 12: Results at Week 24 (LOCF*) in an Active-Controlled Trial of Dapagliflozin Initial Combination Therapy with Metformin HCl Extended-Release in Adults with Type 2 Diabetes Mellitus Dapagliflozin Add-On To Metformin HCl Immediate-Release A total of 546 adult patients with type 2 diabetes mellitus with inadequate glycemic control (HbA1c 7% and 10%) participated in a 24-week, placebo-controlled trial to evaluate dapagliflozin in combination with metformin HCl (NCT00528879)

This dual approach may result in better HbA1c reduction than either medication alone, as suggested by meta-analyses of GLP-1 receptor agonists combined with SGLT2 inhibitors, potentially allowing some patients to achieve their glycaemic targets more effectively

Specifically, there is a significant link between the use of this medication and the levels of a critical molecule called glutathione

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[DOI] [PubMed] [Google Scholar] 44.Jones DP, Go YM

nevertheless, they are only found in trace levels