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Among upstream regulators of ferroptosis in IBD, hypoxia-inducible factors (HIFs) occupy a unique position by integrating hypoxic stress, iron homeostasis, and inflammatory signaling, thereby setting the threshold at which epithelial ferroptosis is triggered

In regressed melanoma, the melanin pigment is coarse and irregularly distributed within the cytoplasms of melanophages, which contrasts with the fine granular pattern of deposition seen in the neoplastic melanocytes in animal-type melanoma

Pasing Y, Fenton CG, Jorde R, Paulssen RH

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Plant Cell Physiol 22(5):867880 Noctor G, Mhamdi A, Chaouch S, Han YI, Neukermans J, Marquez-Garcia BELEN, Foyer CH (2012) Glutathione in plants: an integrated overview