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Severe gastrointestinal disease, particularly gastroparesis, may alter both efficacy and tolerability and requires careful consideration

Under the Dietary Supplement Health and Education Act (DSHEA), these products are regulated as foods, not medications, and manufacturers cannot legally claim they treat, cure, or prevent disease

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People with obesity also may have worse breast cancer outcomes compared to those without excess body weight

Since it mimics both GLP-1 and GIP, it may be more effective than semaglutide

The first patient, treated in 1906, was a 50 year old dying man who had just had his toe amputated due to gangrene from diabetes and was in a diabetic coma