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GLP-1 receptor agonists such as semaglutide established that pharmacologic activation of gut hormone pathways could produce double-digit percentage weight loss in many patients

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Microbes like Coprococcus and Faecalibacterium also produce acetate, butyrate, and propionate, which are known to affect the immune, endocrine, and nervous systems (Valles-Colomer et al., 2019)

Furthermore, the influence of H.p reaches distant organs via axes such as the gut-lung axis, where infection in infancy can alter the lung microbiome and associated inflammation (Siegel et al., 2024), and the microbiota-gut-brain axis, thereby increasing the risk of neurological disorders such as post-stroke depression (Sun et al., 2024

Activation of adrenalin/2-adrenoreceptor/cAMP/MITF and of noradrenalin/1-adrenoreceptor/cAMP/MITF also induces melanin biosynthesis and arborisation of melanocytic dendrites

Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation