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The microneedles painlessly penetrated the skin and efficiently delivered aPD1 to the tumor microenvironment, with the NPs in each needle containing both aPD1 and a glucose-specific enzyme for controlled and sustained release (Fig

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Fasted Constraints: Plasma glucose and insulin are potent inhibitors of somatotroph cell secretion

10.1016/j.taap.2022.116043 5 AgrawalS.KhazaeniB