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The sc infusion was necessary because the GLP-1 molecule is cleared extremely rapidly in the body (intravenous (IV) half-life of 1-2 min.) due to the actions of an enzyme, dipeptidyl peptidase 4 (DPP-4), which inactivates the peptide [13]

These studies demonstrate that H

D., Nau, M

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Parr-Brownlie, Reducing neuroinflammation via therapeutic compounds and lifestyle to prevent or delay progression of Parkinsons disease, Ageing Research Reviews, Volume 78, 2022, 101618

The in vitro activity of IDE was studied using either partially purified cytosolic enzyme from male Sprague-Dawley rats, or purified rat recombinant enzyme