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Therefore, it has been suggested that increased GPx activity could be a response to increased lipid peroxidation, resulting from riboflavin deficiency ( Reference Rao and Bhat 29 )

Transcriptional regulation of MnSOD by manganese in the liver of manganese-deficient mice and during rat development

This molecule acts as a primary defender against oxidative stress

Third, discuss monitoring

To further mitigate risk, many studies involve sentinel subjects typically only 1 participant on the active drug and 1 on placebo who receives the investigational drug before the remaining participants in the cohort are dosed