The main concern is stacked GI side effects - both compounds slow digestion through different pathways, so combining them can amplify nausea, vomiting, and constipation
Other common side effects associated with GLP-1s include constipation, loss of muscle mass or bone density, and, less commonly, abdominal pain, according to the Obesity Action Coalition
GLP-1 RAs prevent the liver from releasing too much sugar, which helps to keep your fasting glucose levels from rising too high
Metabolic Flexibility Retatrutide may influence: insulin sensitivity, visceral fat, body composition, and overall metabolic function
Would retatrutide be reviewed as a traditional drug, or would it ultimately be regulated as a biologic
Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis