To overcome these limitations, this review discusses a range of structural modifications, including N-terminal and C-terminal substitutions, fatty acid conjugation, and large molecule fusion technologies, which have collectively contributed to enhanced half-life, increased stability, improved receptor affinity, and retained or augmented bioactivity of GLP-1 analogs
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GLP-1 and GIP/GLP-1 drugs have strong Phase 3 efficacy and clear FDA-approved labels for weight management
Clinical development of oral semaglutide for the treatment of type 2 diabetes mellitus: Focusing on early phase clinical trials
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Neurodegenerative diseases - is metabolic deficiency the root cause
