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(2012) toxicity [PMID: 23170960] PubMed/Clinical Trials: Wessells et al

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While little information is available regarding the role of aescin in regulating hyperthyroidism, few researchers, such as Panda and Kar 70 , have suggested that the saponin component may inhibit thyroid hormone production and release at both glandular and peripheral levels

Analyses of TCGA data and quantitative immunohistochemical analysis (IHC) of a clinically annotated tumor tissue microarray (TMA) showed that low EPAC mRNA and RAP1-GTP (active RAP1) protein levels correlate with better disease (recurrence)-free survival of patients diagnosed with primary melanoma

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