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The active form of B12 in this formulation is methylated and, thus, highly bioavailable

However, your personal experience with side effects, daily routine, and work schedule can guide when to administer your dose for maximum comfort and adherence

doi:10.1017/S1461145711000617, PMID: 21733244 Gawryluk JW, Wang JF, Andreazza AC, Shao L, Young LT (2011) Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders

Lam, E.W.N

Linus Pauling Institute Oregon State University Updated in April 2014 by: Giana Angelo, Ph.D

Patients using timed hydration report 60-70% fewer dehydration-related symptoms in the first 8 weeks compared to ad-hoc drinking (pattern observed across FormBlends patient feedback, not a controlled trial)