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Semaglutide, by contrast, is FDA-approved under the brand names Ozempic (for diabetes) and Wegovy (for weight management)

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In phentermine and topiramate extended-release clinical trials, the peak reduction in serum bicarbonate typically occurred within 4 weeks of titration to the assigned dose, and in most patients, there was a correction of bicarbonate by week 56, without any dosage reduction