Managing gastrointestinal side effects of GLP-1 receptor agonists in clinical practice
These compounds offer distinct advantages over their peptide-based counterparts, including oral bioavailability, improved patient adherence, and the potential for broader therapeutic applications
Red flags include severe bloating with a swollen, hard belly, inability to pass gas, and no bowel movements [13]
however, total government costs would still outweigh savings
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To address this limitation, research has concentrated on many strategies, including identifying and developing DPP-IV inhibitors 43,44 , altering the structural makeup of GLP-1, searching for structural analogues that are more resistant to DPP-IV cleavage 45 , and increasing its hydrodynamic radius ( R h) above the glomerular filtration cutoff by conjugating it to proteins such as transferrin 46 , albumin 47 , and elastin-like polypeptides 48
