how does tirzepatide work vs semaglutide or Semaglutide vs. Tirzepatide Weight Loss:

GLP-2 rapidly activates divergent intracellular signaling pathways involved in intestinal cell survival and proliferation in neonatal piglets

2012;7(1): e30948

When size matters - hyperplastic and hypertrophic obesity and insulin resistance WAT expands through adipocyte hypertrophy (an increase in cell size) and/or the formation of new adipocytes via adipogenesis (hyperplasia), resulting in enhanced lipid storage

Some have reported vomiting, reflux, and constipation

Doses may be adjusted for specific concerns like liver support

In fact, the only study that I could find involving humans was a very small retrospective study with just 16 participants