Future GLP-2 trials in IBD should stratify patients by disease phenotype (mucosal UC, inflammatory CD, stricturing CD) and incorporate serial cross-sectional imaging to monitor for stricture progression, given the mechanistic link between GLP-2R signaling through subepithelial myofibroblasts and intestinal fibrogenesis
Some transition to lower maintenance dose, others stop after establishing healthy habits
This sustained action leads to a far stronger effect on appetite suppression and blood sugar control than what the body can achieve naturally, which is why these medications are highly effective treatments for type 2 diabetes and obesity
No trial has directly compared the two, so this is an indirect comparison across trials rather than a measured difference
Prioritize Healthy Sleep Sleep is one of the most overlooked aspects of metabolic health
More significant weight losssuch as losing 5% or more of your initial body weighttypically occurs over a longer period, often within 3 to 6 months of consistent use