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That problem is very real

Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR

Moreover, caspases were found not to be recruited in response to multiple proapoptotic stimuli [189]

More recently, surface functionalized graphene quantum dots (GQDs) have been shown the capability to cross the bloodbrain barrier and exert synergistic photodynamic and photothermal effects in combination with chemotherapeutic doxorubicin and temozolomide (84, 85)