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7.5 Saponins: guardians of mitochondrial integrity and lipid peroxidation Saponins protect against ALD by inhibiting CYP2E1 to reduce ROS generation during ethanol metabolism, while PPAR- activation promotes fatty acid -oxidation and HDL synthesis (Yang et al., 2021a

Meal Timing and Frequency The combination of reduced appetite and slowed gastric emptying makes traditional three-meal structures impractical for most users

Singapore: 2019

10.1007/s10522-006-6495-x Biogerontology 15 BalasaR.BarcuteanL.BalasaA.MotataianuA.Roman-FilipC.ManuD

Adequate hydration (at least 2-3 liters daily), fiber supplementation, and magnesium citrate at bedtime are the first-line approaches

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