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2002;8(11):BR439-443

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(PubMed) Turker O, Kumanlioglu K, Karapolat I, Dogan I

PMC 2813894

Lavie CJ, Howden CW, Scheiman J, Tursi J

Prolonged-release melatonin (available by prescription in some countries, or as extended-release OTC formulations) maintains melatonin levels through the night and has more evidence for improving overall sleep quality.[3] For women aged 55 and older, prolonged-release melatonin is considered a first-line pharmacologic option for insomnia by some guidelines, primarily because its safety profile is favorable compared to other sleep medications.[3] It doesnt carry the cognitive risks, fall risks, or dependence potential of benzodiazepines or Z-drugs