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Recent studies also highlight the role of perivascular adipose tissue (PVAT), which, when becoming dysfunctional and lipid-laden, loses its vasoprotective properties and secretes pro-inflammatory adipokines directly onto the adjacent arterial wall, creating a localized inflammatory milieu that accelerates atherosclerosis (103) (As shown in Figure 4 )

Artmed Nicassio L, Fracasso F, Sirago G, Musicco C, Picca A, Marzetti E, Calvani R, Cantatore P, Gadaleta MN, Pesce V (2017) Dietary supplementation with acetyl- l -carnitine counteracts age-related alterations of mitochondrial biogenesis, dynamics and antioxidant defenses in brain of old rats

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