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Accessed Mar 27, 2025

Sawares et al

Flint A, Kapitza C, Zdravkovic M

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However, peptides have intrinsic weak points, and they did not provide encouraging results in vivo , likely due to their physical, chemical and structural instability and low membrane permeability (112, 119, 121)

The main outcomes evaluated for certainty were body weight reduction, HbA1c, total daily insulin dose, CGMderived metrics, severe hypoglycaemia, DKA/ketosis, gastrointestinal adverse events, and treatment discontinuation