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Abstract The unprecedented clinical success of glucagon-like peptide-1 (GLP-1) receptor agonists has transformed the therapeutic landscape for obesity, diabetes, and cardiometabolic disease, while simultaneously reshaping long-standing perceptions of peptide-based therapeutics as biologically compelling but pharmacologically impractical

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As emphasized in one study, protection from degradation alone does not guarantee trans-epithelial transport or meaningful systemic exposure

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supplementation can replenish depleted stores (Wang et al

Moreover, no serious adverse reactions, renal or liver toxicity were observed (Panigrahi and Mohanty, 2023)