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This shift reflects a broader recognition that health interventions should be tailored to individual needs, genetic predispositions, and lifestyle factors

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Homozygous NKO mice exhibit embryonic lethality [68], whereas heterozygous NKO mice exhibit IGT due to impaired insulin secretion [68] and heart failure due to progressive mitochondrial dysfunction induced by pressure overload [69]

Clin Endocrinol 81(4):588592