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Deletion of Glp1r in VSMCs of mice with C57BL/6 background ( Glp1r VSM/ ) were generated by crossing tamoxifen-inducible Myh11- Cre ER T2 mice (21) (Jackson Laboratory, 019079) with Glp1r fl/fl mice (37, 38), provided by R

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However, the well-recognized pleotropic effects of GLP-1R agonists (normalization of neurogenesis and synaptic plasticity, protection against neuronal apoptosis, and suppression of increased oxidative stress), in conjunction with the presence of GLP-1Rs in the hypothalamic nuclei that regulate sleep and wakefulness, suggest several possible direct effects of GLP-1R agonists in affecting sleepiness and other related parameters (memory, anxiety, and depression) [77, 114]

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Turnock LA, Hearne E, Lazuras L