But the truth is a bit more nuanced, and getting this wrong can fundamentally compromise your research data
Where it has been examined, all HLA-I binding KIR exhibit peptide-dependent recognition of HLA-I with peptide positions 7 (p7) and p8 (of 9mers) proving most critical for receptor engagement [6, 13, 14]
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For labs making oxidative stress, ferroptosis, metabolic damage or signal transduction models, CBS activity can provide the critical distinction between upregulation of interest and upregulation of artifact to separate out expression changes from functional changes
