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Therefore, the activation of the IGF-2/IGF-1R axis may contribute to -cell survival in response to GLP-1, and importantly, the increased IGF-2 secretion may be essential for triggering this response, as also observed in embryonic development (41)
110,111 Screening components include routine foot examinations for ulcers and abnormalities, patient education on foot care and early signs of neuropathy, and management of modifiable risk factors such as hypertension, dyslipidemia, and smoking
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