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The mechanistic core of the finding was that Dihexa activated the PI3K/AKT signaling pathway in the brains of the APP/PS1 mice, and that the PI3K inhibitor wortmannin reversed Dihexas anti-inflammatory and anti-apoptotic effects [5]

Friend DM, Devarakonda K, ONeal TJ, Skirzewski M, Papazoglou I, Kaplan AR, Liow JS, Guo J et al (2017) Basal ganglia dysfunction contributes to physical inactivity in obesity

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Yanagi, S., Sato, T., Kangawa, K