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Some people report that their skin feels smoother and looks more even-toned during this period

Cells were imaged in fresh FluoroBrite DMEM supplemented with 4 mM glutamine, 1 mM sodium pyruvate, 10% FBS and penicillin (100 U ml 1 )/streptomycin (100 g ml 1 )/fungizone (0.25 g ml 1 )

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Acknowledgments We thank Masayuki Yamamoto (Tohoku University) and Michinori Hirata (Chugai Pharmaceutical Co

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