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Duration of treatment comparison Trial duration differences complicate raw comparisons

Knop, et al (2007)

Two emerging pharmacological classes may challenge its risk-reward calculus: Oral GLP-1 agonists (e.g., oral semaglutide, danuglipron): These offer dosing convenience and eliminate injection site reactions, but bioavailability remains problematic (oral semaglutide achieves only 0.41% absorption, requiring daily dosing and strict administration protocols)

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doi: 10.1186/S44158-025-00237-Y 107 SherwinMHamburgerJKatzDDeMariaS