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In a pilot trial evaluating 104 amnestic MCI and early-stage AD patients, 20 IU and 40 IU doses of intranasal insulin improved Alzheimers Disease Assessment Scale-Cognitive subscale (ADAS-Cog 12) scores compared to placebo-treated patients, with improvements in delayed recall observed 2 months following cessation of treatment in the 20 IU group

Due to its structure, skin lipids can be packed tightly and in turn, this strengthens the barrier and reduces water loss