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The company plans to submit orforglipron for approval as an obesity medication to global regulatory agencies by the end of the year, and as a diabetes medication in 2026

[DOI] [PubMed] [Google Scholar] 157.Garca-Prez-de-Sevilla G., Gonzlez-de-la-Flor

If genetic testing reveals reduced GLP-1 pathway responsiveness, switching to tirzepatidewhich targets both GLP-1 and glucose-dependent insulinotropic peptide (GIP) receptorsmay unlock the weight loss you've been missing

FDA.gov ClinicalTrials.gov