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Severe glutathione depletion permits these intermediates to damage hepatocytes

Since -Klotho is not expressed in pituitary adenoma, elevated sKlotho levels are most likely due to increased renal -Klotho and consecutively, enhanced cleavage of its extracellular domain as the main source of sKlotho ( vide supra ) [112, 113]

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The peptide does not appear to accumulate in specific organs and is cleared renally as degraded fragments

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