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Stay at current dose if: GI symptoms are still present but manageable

de Jess Garduno-Garcia J, Gastaldelli A, DeFronzo RA, Lertwattanarak R, Holst JJ, Musi N

For optimal tolerance, consider: Starting with a lower dose : Begin with a smaller amount and gradually increase if needed Dividing doses : Taking smaller amounts twice daily rather than a single large dose may improve tolerance Consistency : Taking supplements at the same time daily supports adherence Patients experiencing persistent nausea from GLP-1 therapy might temporarily reduce magnesium supplementation during dose escalation periods, then resume once symptoms stabilise

Twice-daily dosing during the first 1-2 weeks followed by once-daily dosing is a commonly described approach in the research community

doi: 10.1210/jcem.83.8.5007

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