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Among Nrf2-regulated genes, HO-1 is the most well known as a stress protein that can have both antioxidative and anti-inflammatory effects [84]
Exceptional tumour responses to fasting-mimicking diet combined with standard anticancer therapies: a sub-analysis of the NCT03340935 trial
Andrographolide is the major active component of AP, exhibits diverse pharmacological activities, including anti-inflammatory, antioxidant, and antidiabetic activities ( In vitro and in vivo studies demonstrated that Rg1 down-regulated MDA and ROS, up-regulated SOD, increased the expression of Bcl-2 protein, decreased the activity of proteins such as Bax, cleaved cystathionase-3, and cleaved cystathionase-9, and effectively inhibited the oxidative stress response and reduced apoptosis in rats with DN ( 3.3.2 Steroidal saponins Diosgenin (DIO) is a plant sterol saponin, since time immemorial, DIO and its derivatives, which are obtained from the rhizomes of Dioscorea (popularly known as Shanyao in Chinese) are utilized in traditional Chinese medications ( 3.3.3 Flavonoid Formononetin (FMN) is one of the major isoflavonoids isolated from Astragalus, which has been found to have antioxidant activity in some studies ( in vitro experiments and has mitochondrial protective and anti-apoptotic effects (114)
It has also been shown to have superior bioavailability, which means it is easily absorbed and utilised by the body
Interleukin-6 facilitates tumor progression by inducing ferroptosis resistance in head and neck squamous cell carcinoma
