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Lower doses may work but typically require more time to produce noticeable effects

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Characteristics of therapeutic GLP-1R agonists Endogenous GLP-1 is characterized by a very short half-life of only few minutes, as it is quickly degraded by dipeptidyl peptidase-4 (DPP4), an enzyme expressed in many different types of tissues

Further exploration uncovered that canagliflozin had the capability to increase the expression of -H2AX, a marker of DNA damage, and activated the DNA damage response signaling pathway ATM/CHK2