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Palmitoylethanolamide (PEA) is a naturally occurring fatty acid studied to show neuroprotective, anti-inflammatory, antihistamine/mast cell stabilizing, and analgesic properties

[DOI] [PubMed] [Google Scholar] 95.Huang H.S., Sun D.S., Lien T.S., Chang H.H

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Vigorous shaking denatures the peptide, breaking the molecular bonds that make it functional