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doi: 10.2147/CLEP.S37559

Despite these suboptimal geometries, both chimeras retained potent degrader activity (see previous section), suggesting that degradation efficacy is not strictly dependent on interface energy or complex geometry

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10.1113/jphysiol.2006.122671 79 LeeS.CampomanesC.SikatP.GreenfieldA.AllenP.McEwenB

As enrollment expands across the study, zero serious adverse events have been reported across all subjects dosed to date, and the company continues to target a Phase IIa data readout in Q4 2026