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The Endocrine Society guidelines on GH and IGF-1 therapy note that serum IGF-1 should be maintained within age-adjusted normal range to avoid acromegaloid effects

AursnesISmithPArnesenHkessonB

doi:10.1111/j.1463-1326.2006.00591.x

314 , L256L275 (2018)

Can bacteria or their endotoxins penetrate the intact intestinal epithelium in normal humans [59, 71] or animals through the intestinal cells themselves or through the intercellular junctions, or can BT occur only through damaged intestinal epithelium