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Furthermore, locomotor responses to cocaine and alcohol self-administration are attenuated in GHSR1a- and ghrelin-deficient mice and rats (Jerlhag et al., 2010

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Pharmacological activation of Nrf2 enhances the expression of cytoprotective genes, conferring resistance against oxidative injury and fibrogenesis in DKD models (242)

These improvements were also linked to enhanced cerebrovascular function

Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model