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In a single piece, he concisely captures: the state of the field the most important clinical trials where the pipeline is headed These Clinical trials are raising the bar and expanding future treatment options: Retatrutide ~24% weight loss (triple agonist) MariTide 1216% weight loss (GLP-1 + GIP antagonist) CagriSema up to 20% weight loss + ~2% HbA1c drop Orforglipron oral GLP-1, HbA1c 1.5%, weight 7.6% IcoSema weekly semaglutide + once-weekly insulin Even more exciting
Diabetes is defined as: Hemoglobin A1C 6.5% , or A documented history of diabetes at any time in the past
Medical weight loss combines clinical expertise with advanced therapies to help you achieve and maintain a healthy weight
They can support digestive function and gut integrity (important if gastric emptying is slowed)
doi: 10.1056/NEJMoa1612917 19 LeiterLACarrMCStewartMJones-LeoneAScottRYangFet al
GLP-1s appear to stand alone in producing results like that across all substances at once
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