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Proc Natl Acad Sci USA 104:1765017655

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As GLP-1 has a very short plasma half-life of ~13 min, it is widely believed that at least some of its anorexic action is mediated through activation of GLP1R located on afferent nerve endings in the vicinity of L-cells

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IGF-1 LR3 (Long R3 Insulin-like Growth Factor 1) is an 83-residue synthetic analog of native IGF-1 with an N-terminal 13-residue extension and an arginine substitution at position 3

doi:10.1111/j.1360-0443.2009.02564.x