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Vitamin B12 (Hydroxocobalamin) is a cobalt-containing essential vitamin central to red blood cell formation, nervous system function and methylation pathway support

Nat Chem Biol 4:152156 Luther GW, Rickard DT, Theberge S, Olroyd A (1996) Determination of metal sulphide stability constants of Mn 2+ , Fe 2+ , Co 2+ , Ni 2+ , Ci 2+ , and Zn 2+ by voltammetric methods

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Glutamate Homeostasis Under Depression The 1 H-MRS method has been used extensively for the assessment of glutamate and other metabolite levels in the brain of depressed subjects and rodent models of depression (Table 1)

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It is necessary for other nutrients, such as vitamins C and E, as well as beta-carotene, to support glutathione in this role