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Adiponectin and leptin up-regulate extracellular matrix production by dermal fibroblasts

This mechanism is fundamentally different from the indirect liver benefits seen with GLP-1 single agonists, which reduce liver fat primarily through weight loss and improved insulin sensitivity

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In reality, cost is a major consideration for these weight loss medications, says Alyssa Dominguez, MD, an endocrinologist with Keck Medicine of USC

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Healthy weight loss with either therapy requires careful monitoring and realistic goal setting