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Coskun and colleagues (Cell Metabolism, 2022) provided the foundational characterisation, demonstrating that balanced engagement of all three receptors produces metabolic effects not achievable through dual or single-receptor pharmacology alone

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For patients requiring additional glycaemic control, the dose may be increased to the maximum licensed dose of 2 mg once weekly after at least four weeks at the 1 mg dose, as per the UK SmPC

And Robert, you just mentioned one of the papers that you worked on last year

For the measurement of plasma sodium (Na+) and potassium (K+) ion levels, plasma samples were first diluted by 10-fold

Are willing to collaborate with you and other providers, and to provide clear lab and clinical follow-up