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And when he wrote that book, I met him like eight months later and he told me a story and I've rarely told told people about this, but I'll put this on your podcast
It was initially developed as a scavenger of OH and other ROS, but may exert effects through other mechanisms in vivo [436]
Knop FK, Brnden A, Vilsbll T
Xie Y, Hu H, Liu M, Zhou T, Cheng X, Huang W, et al
Alteration of several metabolic enzymes and pathways that affect KG abundance and KGDD activity have been reported in cancer, such as mutations of the genes encoding isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2), changes in glutaminolysis that deplete KG, and alterations in fumarate hydratase and succinate dehydrogenase that inhibit KGDD activity 11
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