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The parabolic, or U-shaped figure, below displays how the level of nutrient concentration or intake (x-axis) relates to an antioxidant measure (y-axis)

(6) Therapeutic efficacy is highly time sensitive, with optimal outcomes occurring prior to completion of the aging process and markedly reduced oxime responsiveness after the post-aging window

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(3) A Bjartell, R Ekman, S Bergquist, and E Widerlv (1989) Reduction of immunoreactive ACTH in plasma following intravenous injection of delta sleep-inducing peptide in man Psychoneuroendocrinology, 1989, Volume 14 (Issue 5), Pages 347-55